Targets of these proteins are host laminin and fibronectin, protein components of extracellular matrix. Fibronectin is present on endothelial and epithelial surfaces and takes part in blood clots structure promoting adhesion. Clumping factor is a fibrinogen/fibrin binding protein that promotes attachment to blood clots. An adhesin with high affinity for collagen takes an important role in developing osteomyelitis and damaged tissue infections (as a result of adherence assays on mutants strains).