• Cannabinoid Agonists
    • Natural Cannabinoids
  • Structure - Activity Relation (SAR)
  • Endocannabinoids
    • biosynthesis
    • biological action
    • psyiopathology
 
 
 

Natural Cannabinoids

Beyond 400 different substances have been identified in the Cannabis sativa, and more than 60 belong to the cannabinoids family.

GroupAbbreviationKnown variations
D9-TetrahydrocannabinolD9-THC9
D8-TetrahydrocannabinolD8-THC2
CannabicromeneCBC5
CannabicyclolCBL3
CannabidiolCBD7
CannabielsoinCBE5
CannabigerolCBG6
CannabinidiolCBND2
CannabinolCBN7
CannabitriolCBT9
Others 11
Total 66

The delta-9-tetrahydrocannabinol (D9-THC) is generally considered the prototype of this family of substances and researches focused particularly on it, however it is not the only active principle of the Cannabis, in fact it contains many others, some of which have interesting therapeutic properties.

Among these it is worth especially remembering the cannabidiol (CBD). It's a cannabinoid with no psychoactive properties, that's to say lacking in brain effects, but however able to modulating the action of the THC at cerebral level, extending it's duration of action and limiting it's side effects. Moreover CBD boasts a real efficacy as anticonvulsant and analgesic drug.

THC logo
D8-THC
CBN
CBD
D9-THC